Kisspeptin 5mg
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Description
Kisspeptin 5mg
Kisspeptins (including kisspeptin-54 (KP-54), formerly known as metastin) are proteinsencoded by the KISS1gene in humans. Kisspeptins are ligandsof the G-protein coupled receptor, GPR54.[5]Kiss1 was originally identified as a human metastasis suppressorgene that has the ability to suppress melanomaand breast cancer metastasis.[6] Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty, the extent of which is an area of ongoing research.[7]Gonadotropin-releasing hormone is released from the hypothalamus to act on the anterior pituitarytriggering the release of luteinizing hormone (LH), and follicle stimulating hormone (FSH). These gonadotropic hormones lead to sexual maturation and gametogenesis. Disrupting GPR54 signaling can cause hypogonadotrophic hypogonadism in rodents and humans. The Kiss1 gene is located on chromosome 1. It is transcribed in the brain, adrenal gland, liver, gonads, and pancreas.
