Pure 5-Amino-1mq

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Pure 5-Amino-1mq

Price range: $30.00 through $145.00

Buy 5-Amino-1MQ vials and kits online.. Verifiable COAs and fast shipping via FedEx 2 day delivery.

Strength

Clear

SKU: N/A Category: Uncategorized

Description

5-Amino-1Mq

5Amino-1MQ is a small molecule that inhibits NNMT (nicotinamide N-methyltransferase), an enzyme involved in nicotinamide metabolism. By blocking NNMT, it may support cellular NAD+ levels and metabolic function.

Unlike traditional amino-acid-based peptides, 5-Amino-1MQ is a small molecule. It is not currently approved by the FDA for human use and remains primarily a research compound. While it is sometimes available through specialized or compounding pharmacies in personalized wellness settings, scientific safety data and published human trials are currently limited. [1, 2, 3, 4, 5]

Properties

assay

≥99% (HPLC)

form

Lypholized powder

color

faint orange/red to dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

5-Amino-1-methylquinolinium is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀ = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC₅₀ = 30μM) and adipocytes 1-methylnicotinamide level (EC₅₀ = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathway. 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid. sc.), and intraperitoneal HeyA8 ovarian cancer metastasis (20 mg/kg/d ip.) with no adverse effects to the animals (up to 60 mg/kg/d). Note:1.89 mg iodide salt contains 1 mg eq of 5-amino-1MQ.

Substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor with in vitro and in vivo efficay.

Additional information

Strength	5mg, 10mg, 50mg, 100mg

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